A Type 1 Diabetes Lifestyle Website
A cure for Type-1 diabetes has come closer with the development of a new method for keeping transplanted insulin-producing cells alive and functional in recipients for long periods even when transplanted underneath the skin. A team led by researchers at the Perelman School of Medicine reports the new method, and its successful testing in multiple […]
Researchers at Karolinska Institutet in Sweden have deciphered the diabetogenic role of a certain type of calcium channel in insulin-secreting beta cells. The researchers believe that blockade of these channels could be a potential new treatment strategy for diabetes. The study is published in the scientific journal PNAS. CaV3.1 channels have a marginal role in […]
The ISLET project, a multi-center collaboration of leading European researchers, aims to develop a manufacturing pipeline for stem cell-based products to treat patients with Type 1 Diabetes. In Type 1 Diabetes a patient’s immune system destroys the beta cells within the islets of Langerhans in the pancreas making a patient depend-ent on life-long delivery of […]
A new device which makes it easier to perform islet cell transplantation has been created, called ‘Islet-on-a-Chip’. Developed by Harvard University, Islet-on-a-Chip will make it easier for experts to screen for insulin-producing cells before they are transplanted into a person. The device was inspired by fully functioning human pancreases – which produces our body’s insulin […]
The primary cause of the loss of functionality in transplanted pancreatic islets is their low capacity to create new vessels to transport nutrients. Researchers from the University of Barcelona and IDIBAPS have led a study that identifies a protein as the potential modulator in the revascularization of pancreatic islets. In the study, conducted on diabetic […]
Scientists have developed a way to increase the effectiveness of pancreatic islet transplantation, a promising therapy for type 1 diabetes. New findings could make pancreatic islet cell transplants more effective. Immune rejection by the recipient is a major barrier to pancreatic islet transplants from donors becoming routinely available for the treatment of type 1 diabetes. […]
By the time type 1 diabetes is diagnosed, most of the insulin-producing beta cells have already been destroyed. Now, using an innovative transplantation technique, researchers at Karolinska Institutet and University of Miami Miller School of Medicine have been able to intervene to save the beta cells in mice by discovering early signs of the disease. […]
An implantable “teabag” device could be used to treat children with type 1 diabetes in the future, researchers have said. A team from the Department of Surgery and Medical Imaging at the University of Arizona College of Medicine are among the many scientists worldwide exploring the exciting field of islet cell encapsulation. Islet cell encapsulation […]
Typically, only pancreatic beta, which lack in people with type I diabetes, cells can produce insulin. Pedro Herrera and colleagues investigated whether human pancreatic alpha and gamma cells from diabetic and non-diabetic donors could be reprogrammed to produce insulin in response to glucose. The authors report that increased expression of two key transcription factors (Pdx1 […]
It is said that the eyes are the window to the soul, but they may also open the door for discovering new ways to achieve immune tolerance to transplanted islets in type 1 diabetes, according to research from the Diabetes Research Institute (DRI) at the University of Miami Miller School of Medicine. The findings, which […]