Ready-to-Use Glucagon effectively maintains blood sugar during exercise in type 1 diabetes

Delhi: A novel ready-to-use liquid stable glucagon was effective in maintaining euglycemia (normal levels of blood sugar) during prolonged, continuous, intense aerobic exercise in patients with type 1 diabetes, according to a recent study published in the journal Diabetes.
Ronnie Aronson from Canada and colleagues evaluated the safety and efficacy of a novel ready-to-use liquid stable glucagon (RTUG; Xeris Pharmaceuticals) for the prevention of exercise-induced hypoglycemia (EIH) during and after moderate-to-high intensity aerobic exercise.
For the purpose, the researchers conducted a phase 2 randomized, placebo-controlled, double-blind, clinical research center (CRC) crossover stage, followed by a 12-week 3-arm parallel Outpatient stage. It enrolled 48 adults with type 1 diabetes who were using an insulin pump. In the outpatient stage, subjects were assigned to RTUG 150 μg plus 50% basal insulin pump reduction, or RTUG 150 μg with no insulin change, or to placebo. Blood sugar was measured by blood sugar meter before, during, and after moderate-to-high intensity, aerobic exercise to evaluate the incidence and severity of hypoglycemia. Continuous glucose monitors were utilized in the CRC and Outpatient stage.
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