Bone turnover markers decreased in children with type 1 diabetes

A cohort of children and adolescents with type 1 diabetes had markers of bone formation and bone resorption that were significantly decreased compared with children without diabetes, independent of diabetes duration and Tanner stages, according to findings published in Pediatric Diabetes.

“The take-home message from the study is that bone turnover is altered in children and adolescents with type 1 diabetes, and metabolic outcomes in the form of HbA1c are associated with markers of bone resorption,” Jens Otto Broby Madsen, MD, PhD, of the department of pediatrics and adolescent medicine at Herlev Hospital, Denmark, told Healio. “This association is a potential explanation of the common finding of decreased bone mineral density among adults with type 1 diabetes and has also been hypothesized as the cause of altered microarchitecture found in recent studies of children and adolescents.”

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