Blood signature for β-cell autoimmunity -- potential tool for disease prevention

Using cutting-edge genomics methods a gene signature predicting type 1 diabetes was discovered. This signature is detectable already before the appearance of type 1 diabetes associated autoantibodies. The finding could help in identifying early on the children who are likely to develop the disease later.

The incidence of type 1 diabetes is record high in Finland, but the reason for this is unknown. However, the appearance of autoantibodies associated with type 1 diabetes indicates a likelihood to develop the disease.

An international study led by scientists from the Turku Bioscience Centre at the University of Turku, Finland, identified an early gene signature in children who will later develop type 1 diabetes – even before the appearance of the associated blood autoantibodies.