Sernova touts first-in-human results from insulin-secreting cell implant for diabetes

In the first patient to receive its pancreatic cell implant for type 1 diabetes, Sernova’s insulin-secreting Cell Pouch showed no adverse events related to the therapy, and was able to help maintain blood sugar levels over at least two weeks.

In interim results from the phase 1/2 study, the transplant of purified islets demonstrated the production of insulin as well as stimulated C-peptide, a biomarker of the pancreas’ effectiveness in responding to rising glucose levels after eating.

Additionally, the regenerative Cell Pouch was found to integrate well with the blood and lymph vessels of the patient—who saw a weight loss of about 14 pounds (6.35 kg), or about 12% of total body weight.

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