Can the eye help achieve islet transplant tolerance in type 1 diabetes?

It is said that the eyes are the window to the soul, but they may also open the door for discovering new ways to achieve immune tolerance to transplanted islets in type 1 diabetes, according to research from the Diabetes Research Institute (DRI) at the University of Miami Miller School of Medicine. The findings, which were published online on January 31st in Diabetologia, the journal of the European Association for the Study of Diabetes (EASD), show that islets transplanted in the eye can survive and function long-term without continuous immunosuppression, and, moreover, that initial islet transplants within the eye of the recipient may lead to long-term peripheral immune tolerance in other transplant sites. The study was conducted in experimental and preclinical (non-human) models of diabetes.


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